Molecular Clues Help Refine Kinase Inhibitor Strategy for GI Molecular Clues Help Refine Kinase Inhibitor Strategy for GI
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Robert G. Maki, M.D., Ph.D., Memorial Sloan-Kettering Cancer Center
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ORLANDO -- In the post-imatinib (Gleevec) era, treatment of gastrointestinal stromal tumors has shifted from serial surgeries to refinement of kinase inhibitor dosing, according to this presentation from the ASCO-GI symposium here.

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Serum Imatinib (Gleevec) Levels Predict GIST Response Serum Imatinib (Gleevec) Levels Predict GIST Response
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George D. Demetri, M.D., Dana-Farber Cancer Institute in Boston
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ORLANDO -- Higher circulating levels of imatinib (Gleevec) correlated with better clinical responses in patients with gastrointestinal stromal tumors (GIST), but proper initial doses were unpredictable, a researcher reported here.

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Use of Tommy John Surgery for Young Elbows on the Rise Use of Tommy John Surgery for Young Elbows on the Rise
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LITTLE FALLS, N.J. -- Pitching with the Double-A Mobile BayBears in August 2003, San Diego Padres prospect Rusty Tucker threw a fastball and felt something let go in his elbow, but the pain didn't come until he tried to throw the next one.

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SIR: Varicocele Embolization Reduces Pain and Infertility SIR: Varicocele Embolization Reduces Pain and Infertility
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Amol Mujoomdar, M.D., of the University of Toronto
WASHINGTON -- A minimally invasive varicocele embolization procedure reduces pain and improves sperm count, according to a retrospective study reported here.

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ACG: Eosinophilic Esophagitis Advances Highlighted at ACG ACG: Eosinophilic Esophagitis Advances Highlighted at ACG
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Walter Coyle, M.D., of the Scripps Clinic in San Diego
ORLANDO, Oct. 9 -- New data on swallowed budesonide (Rhinocort, Pulmicort) for eosinophilic esophagitis and on the condition's origins as an allergic illness created a stir at the American College of Gastroenterology meeting here.

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ASTRO: Medicare HMOs Limiting Clinical Trial Participation ASTRO: Medicare HMOs Limiting Clinical Trial Participation
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Dwight Heron, M.D., University of Pittsburgh Cancer Center
BOSTON, Sept. 23 -- Medicare rules may be keeping older Americans out of cancer clinical trials, researchers said here.

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ACC: ENHANCE Data on Ezetimibe/Simvastatin (Vytorin) ACC: ENHANCE Data on Ezetimibe/Simvastatin (Vytorin)
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Harlan M. Krumholz, M.D., of Yale University
CHICAGO -- The take home message from the ENHANCE trial reported here today is a simple one: it's time for a return to statins.

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ACR: Pegloticase Promising for Treatment-Resistant Gout ACR: Pegloticase Promising for Treatment-Resistant Gout
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John S. Sundy, M.D., Ph.D., Duke in Durham, N.C.
SAN FRANCISCO, Oct. 27 -- Severe refractory gout may respond to intravenous infusion of the investigational agent pegloticase (Puricase), researchers found.

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RSNA: Dysfunctional Prefrontal Cortex May Preserve Bad Memories RSNA: Dysfunctional Prefrontal Cortex May Preserve Bad Memories
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CHICAGO, Dec. 3 -- Patients with stress-related psychiatric disorders sometimes have difficulty suppressing traumatic memories, researchers said here.
The culprit may be a dysfunctional prefrontal cortex, Nivedita Agarwal, M.D., of the University of Udine in Italy, said at the Radiological Society of North America meeting.

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Top Cardiology News of 2007 Top Cardiology News of 2007
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CLEVELAND -- Controversy and COURAGE were the hallmarks of 2007 in the world of cardiology.
In this exclusive MedPage Today face-to-face report, Peggy Peck dissects the year with Steven Nissen, M.D., director of cardiovascular medicine at the Cleveland Clinic and a key player in the top cardiology news stories of 2007.

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